We’re excited to share our newest publication, where we collaborated with Alexandra (Sandra) Smink, Paul de Vos, and Richard Leask to engineer an in vitro perfusion system for human-scale bioartificial tissues.
There has been tremendous progress in the development of artificial organs, especially in diabetes cell therapy, which inspired us to create a system designed to bring these cutting-edge technologies closer to clinical applications. In our article titled “Oxygenation and Function of Endocrine Bioartificial Pancreatic Tissue Constructs Under Flow for Preclinical Optimization,” we present a perfusion system that enables the study of viability, function, and even vascularization of cm-scale tissue constructs over multiple days. For those familiar with our work, you’ll know that oxygen transport is a major limiting factor in scaling lab tissues to human applications. In this study, we demonstrate how our system can leverage three of the most prominent mechanisms of mass transport: internal flow (pre-vascularization), passive diffusion, and micro-vascularization post-transplantation.
Check out the full, open-access article here: https://journals.sagepub.com/doi/10.1177/20417314241284826
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