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🎉 New Publication: A System Bridging Bioartificial Pancreas Technology and Clinical Applications

Writer: Hoesli LabHoesli Lab

We’re excited to share our newest publication, where we collaborated with Alexandra (Sandra) Smink, Paul de Vos, and Richard Leask to engineer an in vitro perfusion system for human-scale bioartificial tissues.


There has been tremendous progress in the development of artificial organs, especially in diabetes cell therapy, which inspired us to create a system designed to bring these cutting-edge technologies closer to clinical applications. In our article titled “Oxygenation and Function of Endocrine Bioartificial Pancreatic Tissue Constructs Under Flow for Preclinical Optimization,” we present a perfusion system that enables the study of viability, function, and even vascularization of cm-scale tissue constructs over multiple days. For those familiar with our work, you’ll know that oxygen transport is a major limiting factor in scaling lab tissues to human applications. In this study, we demonstrate how our system can leverage three of the most prominent mechanisms of mass transport: internal flow (pre-vascularization), passive diffusion, and micro-vascularization post-transplantation.


Check out the full, open-access article here: https://journals.sagepub.com/doi/10.1177/20417314241284826 

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McGill University, Department of Chemical Engineering, Wong 4300

3610 University Street, Montréal, QC, Canada H3A 0C5

Tel 514.398.4275 E-mail corinne.hoesli@mcgill.ca

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